Acori Graminei Rhizoma(AGR) has been used in Korea for many centuries as a therapeutic agent for cerebral disease. The effect of AGR on the vascular system is not known. The purpose of this study was to determine the effect of AGR on the pial arterial diameter of male Sprague-Dawely rats. The changes in pial arterial diameter were determinated by video microscopy methods and video analyzer.
The results were as follows ;
1. Pial arterial diameter was increased by AGR in a dose-dependent manner.
2. Pretreatment with 1H[1,2,4]oxadizolo[4,3-a]quinoxalin-1-one(ODQ, 3μM, i.v.) significantly inhibited AGR induced increased pial arterial diameter.
3. Pretreatment with N^G-nitro-L-argirinine(-NNA, 1㎎/㎏, iv) significantly inhibited AGR induced increased pial arterial diameter.
These results suggest that AGR causes a diverse response of pial arterial diameter. The increased in pial arterial diameter is also mediated by nitric oxide synthase and cyclic GMP(guanylyl cyclase).
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